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 Biosense Laboratories AS
 Thormøhlensgt. 55
 Bergen, N-5008,
 Norway
 Tel:(+47) 55543966
 Fax:(+47) 55543771
 E-Mail: biosense@biosense.com

 Webshop by Digitroll

26.01. 2013 Azoxystrobin and pyraclostrobin
ELISA kits to test for the fungicides azoxystrobin and pyraclostrobin are now available. Please contact us at biosense@biosense.com for further info.

07.01.11 Microcystins ELISA for serum
The Microcystins ELISA for Serum is an immunoassay for the quantitative and sensitive detection of microcystins and nodularins in human serum samples. For further information on the new immunoassays, please contact us at biosense@biosense.com

14.04.10 Fluoroquinolone and nitrofuran
Biosense Laboratories are pleased to introduce 3 new antibiotic ELISA kits to screen for the antibiotic residues Enrofloxacin, Furaltadone (AMOZ) and Furazolidone (AOZ) as well as an improved fluoroquinolones kit. 

03.02.10 Ab and Std for androgenic ECD testing
This Ab/Std set consists of a polyclonal antibody against spiggin from stickleback (Gasterosteus aculeatus) and a spiggin standard. The Ab/Std set can be used in Enzymed Linked ImmunoSorbent Assay (ELISA) for identifying endocrine active chemicals with androgenic activity in fish using female sticklebacks. 

25.03.09 Biosense will attend the SETAC Europe meeting
Biosense Laboratories AS will attend the SETAC Europe meeting in Göteborg, Sweden (31st May to 4th of June 2009) as exhibitor. We welcome all new and existing customers to visit Biosense representatives at booth number H04:01. Among the news presented at the booth are kits and equipment for environmental monitoring purposes.
See you in Sweden!

04.09.08 Workshop and training course
The NAFC Marine Centre will host a two-day workshop and training course on 17 and 18 September on the rapid testing of shellfish for algal toxins.  All shellfish producers and processors are invited to attend the course, which will be led by Hans Kleivdal of Biosense Laboratories AS. Read more here

05.08.08 Cell Biology Antibodies
38 new antibodies against cell biology relevant targets are  now available from our web-shop. The Ab´s can be used in ELISA and western blot to detect Factor VII & VIII, Tripeptidyl peptidase,  Chromogranin, Interferon, Fibrinogen etc. See complete list here.

27.02.08 Brevetoxin ELISA and Microcystin dipsticks
We are pleased to introduce a 96 well ELISA kit for the detection of Brevotoxin (NSP) as well as two series of dipsticks for detection of microcystin in drinking water and recreational water, respectively.
The assays complement our battery of tests for freshwater and marine algal toxins. Read more about the different assays here

16.11.07 ASP ELISA recommended by EU
In the Official Journal of the European Union, Biosense ASP ELISA for detection of amnesic shellfish poison is recommended as a cost-effective screening method for detection of ASP in bivalve molluscs. See the Official Journal for more info. (Point 17 and Annex I Chapter II).

13.06.07 New Okadaic Acid (DSP) ELISA kit
We are pleased to introduce an antibody-based Okadaic Acid (DSP) ELISA kit, a 96 well microtiter plate format with ready to use, colour coded reagents, which enables simultaneous measurement of multiple samples at a reasonable cost. Read more

For further information of this or any of our other products, please contact us at biosense@biosense.com

15.05.07 SETAC Europe 17th Annual Meeting in Porto
Biosense Laboratories is attending the SETAC-Europe meeting in Porto, Portugal 20-24 May as exhibitor. You are welcome to visit Biosense representatives at Booth number 3.
For further information please contact us at biosense@biosense.com

29.03.07 New Saxitoxin (PSP) ELISA kit
We are pleased to introduce an antibody-based Saxitoxin (PSP) ELISA kit, a 96 well microtiter plate format with ready to use, colour coded reagents, which enables simultaneous measurement of multiple samples at a reasonable cost. The assay range in water is 0.02 - 0.4 ppb (ng/ml). Read more

14.03.07 Lateral Flow tests for plant pathogens
Biosense extend our product range with tests for 16 different plant pathogens. The lateral flow devices allow growers, inspectors and consultants to do rapid, on-site and field diagnosis of viral, bacterial and fungal diseases in plants. Read more..

13.02.07 New anti-sole vitellogenin available
Biosense are pleased to introduce a new antibody for aquaculture - the anti-sole vitellogenin. For further information of this or any of our other products, please contact us at biosense@biosense.com

05.01.07 Norsk Biokjemisk Selskap kontaktmøte
Biosense Laboratories AS will be present at NBS kontakt møte in Lillehammer 1-4 Feb 2007. To arrange to meet with a Biosense representative at the meeting and/or for further information please contact us at biosense@biosense.com

04.01.07 Cylindrospermopsin ELISA kit now available
We are pleased to introduce the direct, Cylindrospermopsin ELISA kit, microtiter plate (96T) for cytotoxin testing. This kit is the second innovative product for rapid, real-time cyanobacterial testing and complements the advanced generation Microcystins/Nodularins (ADDA) ELISA kit for protein phosphate blockers.

Read more about the cylindrospermopsin kit and the Microcystin/Nodularin kit on our webshop

For further information on any of the two kits, please contact us at biosense@biosense.com

2006

20.12.06 Estrogen exposure in cod
The book ”Biological Effects of Contaminants in Marine Pelagic Ecosystems” is now available from SETAC. In the book A. Goksøyr and S.I. Kristiansen from Biosense are co-authors on the chapter 3.11 ”Assessment of estrogen exposure in cod (Gadus morhua) and saithe (Pollachius virens) in relation to their proximity to an oil field”.

More info on the book can be found on the SETAC webside here

07.12.06 NORMAN network in the news
A network of laboratories for monitoring environmental pollutants (NORMAN network, which includes Biosense) sets the standards and connects researchers across the EU. Link to the article in ES&T here..

12.09.06 New homogolous medaka Vtg ELISA kit
A brand new homogolous vitellogenin ELISA kit for medaka (Oryzias latipes) is now available.

A single-lab validation has been performed and shows that the assays performence is excellent:
  • working range 0.1 - 12.5 ng Vtg/ml (125-fold)
  • LOD = 0.05 ng/ml; LOQ = 0.13 ng/ml
  • minimum dilution for plasma 1:25, whole body homogenate 1:25
  • excellent correlation with and higher sensitivity than competitor medaka Vtg kit and Biosense 1. generation kit 
Please contact us at biosense@biosense.com or download the product-sheet here for further information.

More information is also available in our webshop.

21.07.06 ASP kit Approved by AOAC
New Official Method! - Biosense ELISA for Domoic Acid in Shellfish now approved as AOAC OMA 2006.2. This method offers improved sensitivity, has been eagerly awaited by industry stakeholders and other labs employing microplate-based methods, and was also approved in micro-well strip format.

Ref.: http://www.aoac.org/marine_toxins/task_force.htm

01.06.06 Stress proteins in rainbow trout
A paper on the differences in intracellular localization of stress proteins (hsps) in rainbow trout (Oncorhynchus mykiss) is now available online from Comparative Biochemistry and Physiology via the following link.

The paper Development-dependent differences in intracellular localization of stress proteins (hsps) in rainbow trout, Oncorhynchus mykiss, following heat shock (Authored by Jillian L. Rendell, Stephanie Fowler, Amanda Cockshutt and Suzanne Currie) describes how using antibodies specific for salmonid fish, have determined the intracellular localization of hsp70, hsc70 and hsp90 before and after an acute heat shock in juvenile and mature rainbow trout.

Read more about the antibodies here

24.05.06 New fathead minnow Vtg ELISA validation study available
A study describing the single-lab and interlab validation of Biosense's new homologous sandwich ELISA for fathead minnow (Pimephales promelas) vitellogenin is now available online from Aquatic Toxicology via the following DOI link: http://dx.doi.org/10.1016/j.aquatox.2006.02.031.

The paper Development and validation of a direct homologous quantitative sandwich ELISA for fathead minnow (Pimephales promelas) vitellogenin (Authored by Janne K. Eidem, Hans Kleivdal, Kevin Kroll, Nancy Denslow, Ronny van Aerle, Charles Tyler, Grace Panter, Tom Hutchinson, Anders Goksøyr) included a four laboratory interlab-study involving the University of Exeter (UK), AztraZeneca Brixham Environmental Laboratory (UK), the University of Florida, Gainsville (USA), and Biosense Laboratories AS (Norway), and reported excellent performance characteristics. The assay was 4.9 and 78 times more sensitive than the Biosense Carp Vtg ELISA kit (when used for fathead minnow) and a competitor kit, respectively.

The new FHM Vtg ELISA kit can be ordered here.
Contact Biosense for further information.

26.04.06 Visit Biosense at the SETAC-Europe meeting in The Hague
Biosense Laboratories AS is attending the SETAC-Europe meeting in The Hague, NL (7th May - 11th May, 2006) as exhibitor. You are welcome to visit Biosense representatives as well as a representative from Japan EnviroChemicals, Ltd. at booth number 5.

12.05.06 DiagISN workshop
The Nordic Diagnostic Industry Stakeholders Network (DiagISN) is arranging the workshop Commercialisation of research ideas and the early development of the company in Stockholm on May 29th, 2006. (see www.sik.se/diagisn for further info). Frank F. Mikkelsen from Biosense is a member of the network management team, and will attend the workshop.

14.03.06 New antibodies available
Biosense now offers antibodies for detection of stress-inducible proteins (Heat-shock proteins), Heat-shock cognate protein, and an antibody for detection of gonadotropin-releasing hormone. Visit our webshop to read more about our products


09.03.06 New reformatted ASP ELISA test kit
Biosense is happy to announce that our pre-release version of the ASP ELISA kit, a rapid assay for the determination of Domoic acid in shellfish, algal samples, seawater and marine mammal body fluids has now been updated to a more user-friendly format.

The ASP ELISA is reformatted into a 8x12-strip well format, to offer the end user flexible analysis. The kit can now be split and used in 2 separate rounds to analyze 12 samples each time, or the full plate can be used to analyze 36 samples in one round of analysis. To ensure accurate and reliable sample analysis, a free software is provided for the automatic QA of the calibration and sample calculation.

The assay performs with an excellent sensitivity and precision. The calibration range for the ASP ELISA is 10 - 260 pg/mL, and the working range for shellfish is 0,01 - 250 mg/kg.

Assay running time (full plate of sample extracts and standards): 2,5 hours.

The assay is now being reviewed by AOAC for method accreditation.

24.02.06 Zebrafish in functional genomics and aquatic biomedicine
A review paper describing the advantages of the Zebrafish (Danio rerio) as a model for applications in fields such as functional genomics, Aqua biotechnology, biomedicine and eco-toxicology has been published.
Read more in Trends in Biotechnology Volume 24, Issue 1, (January 2006) here

21.02.06 Biosense Laboratories AS celebrates 10 years in business
The company was founded by Professor Anders Goksøyr at the High Technology Centre in Bergen, Norway, on February 21, 1996, based on research and competence in biotechnology and ecotoxicology at the University of Bergen.

Over the last 10 years Biosense has developed unique biomarker-based assays for environmental monitoring and ELISA kits for food safety control. The company is focusing its developments on three areas of applications; endocrine disruptors, marine toxins and chemical contaminants like dioxins, PCB, PAH and brominated flame retardants.

Together with partners, Biosense is today able to offer a complete battery of kits and reagents for environmental monitoring, food safety, product testing and biochemical & biomedical research from our headquarters in Bergen.

For more info please contact our CEO, Audun Wiborg at +47 55543966 or email audun.wiborg@biosense.com

Please also study our product line and services at our webshop

20.02.06 New Cod Vtg ELISA Assay
Biosense is happy to announce that a new vitellogenin ELISA kit for Cod (Gadus morhua) is now available upon request.

The assay performs with an excellent sensitivity and precision:
- working range 0.5 - 62.5 ng Vtg/ml (125-fold) 
- minimum dilution for plasma 1:20
- In house validation: within-day precision (%CV): 4.3-16.1%, between-day precision (%CV): 13.2-23.0% 

The new Biosense Cod Vtg ELISA kit comes with precoated plates, purified lyophilised Cod Vtg and a non-toxic development solution. The total assay time is 2.5 hours.

Contact Sven-Inge Kristiansen for more information.

14.02.06 Review of analytical methods
A review of analytical methods (ELISA, PCR, PPi, Microscopy, and HPLC) for assessing microcystin levels in aquatic environment has been published. The comparative study ranged cost, reliability and simplicity of the methods and judged the ELISA test as the best method for screening environmental water samples.
Read more at IWA Publishing here

19.01.06 EU recommends ASP ELISA
The ASP ELISA has been recommended as an official method to detect ASP toxins by the annual EU CRL/NRL meeting in November 2006, and is expected to be adopted into an updated regulation by June 2007. More details will follow soon.

17.01.06 Extended product range
Biosense now extend our product range with more than 2000 new reagents, kits, and Ab's for biochemical and biomedical research.

The Biochemical tools, manufactured by Cayman Chemical Company, are designed for research within such disciplines as cancer, nitric oxide, neuroscience, apoptosis, oxidative injury and endocrinology.

The new product range includes assay kits for the measurement of eicosanoids, free radical biomarkers, cyclic nucleotides, cytokines, hormones and nitric oxide. In addition, the product line contains a broad range of quality biochemicals including eicosanoids, nitric oxide reagents, and a variety of related lipids, fatty acids, enzymes, and antibodies.

For further information please contact us at biosense@biosense.com and visit our webshop here


2005

21.09.05 Biosense in the news
Biosense has developed a cheaper, rapid test for shellfish that can help processors check that their food products confirm to the EU`s safety standards.
Read what foodproductiondaily.com wrote yesterday here


20.09.05 New medaka Vtg standard
A new and improved Vtg standard will replace the previous medaka Vtg standard available from Biosense. The new standard vials will contain 3-5 ug per vial. Contact Biosense for more information biosense@biosense.com

06.07.05 Fathead minnow VTG ELISA assay
Biosense is happy to announce that the brand new homologous vitellogenin ELISA kit for fathead minnow (Pimephales promelas) is now available. We have performed both a Single-Lab (in-house) and an Interlaboratory Validation according to international guidelines. These show that the assay performs with an excellent sensitivity and precision:
- working range 0.1 - 25 ng Vtg/ml (250-fold)
- LOD= 0.02 ng/ml; LOQ= 0.09 ng/ml for plasma samples
- excellent correlation with and higher sensitivity than competitor fathead minnow Vtg kit and Biosense Carp Vtg kit
- In-house: whitin-day precision (%CV): 4.5%, between-day precision (%CV): 9.9%
- Interlab (4 participants labs): within lab precision (%CV): 16.4, between-lab precision (%CV): 18.6%

The validation reports are available on our website or on request. The new Biosense fathead minnow Vtg ELISA kit comes with precoated plates, direct-labelled detection mAb, concentrated dilution buffer and a non-toxic development solution. The total assay time is 2.5 hours.
Contact Biosense(biosense@biosense.com) for more information.

30.06.05 ASP ELISA demonstrates equal performance to LC-methods
Biosense Laboratories has participated in a Laboratory Proficiency Study organized by QUASIMEME. In the Amnesic Shellfish Poisoning Toxins development exercise DE-9 (Round 39- Exercise 638), 33 laboratories analyzed triplicates of 5 blind samples of mussels, scallop and oysters, using their routine quantitative method of analysis. All the other participants used LC-UV-PDA or LC-MS methods to quantify the studies samples. The data were assessed to obtain assigned values based on the Cofino model, and the participants were ranked after their z-scores. The performance of Biosense (coded AD708) using the ASP ELISA was ranked as 10 of 33, with 100% satisfactory z-scores (11 participants had less than 100% satisfactory z-scores). Despite the fact that the QUASIMEME study is a Laboratory performance study primarily aimed to assess the laboratory, these results demonstrate that the ASP ELISA is a valid alternative rapid assay to elaborate and time-consuming instrumental methods.
Contact senior scientist Dr. Hans Kleivdal (hans.kleivdal@biosense.com) for more information.

02.05.05 SETAC Annual Meeting Lille, France (22-26 May, 2005)
Biosense staff, as well as representatives from Japan EnviroChemical, will be present at this year's meeting in Lille 22-26 of May. We invite all existing and potential customers to booth nr 24 as well as to our poster Development and validation of a homologous quantitative ELISA for fathead minnow Vitellogenin (TUP-4/25)!
And as always you can get the chance to win a free kit in our annual Raffle...see you there!
Contact Biosense for further information (biosense@biosense.com)

AOAC Meeting in Baiona, Spain (April. 11-14 2005)
The AOAC Presidential Task Force on Marine and Freshwater toxins will meet to discuss new methods, both during specific sub-group discussions and in plenary meetings. Senior scientist Dr. Hans Kleivdal will attend the meeting as an industry expert member, but will also perform oral presentations and practical demonstrations of two assays for the determination of marine biotoxins - the ASP ELISA and the YTX ELISA.
Contact senior scientist Dr. Hans Kleivdal (hans.kleivdal@biosense.com) for more information.

22.02.05 New homologous fathead minnow VTG ELISA assay
Biosense is happy to announce that the brand new homologous vitellogenin ELISA kit for fathead minnow (Pimephales promelas) is nows available. For a limited time period, the kit will be offered at a 50% discount as a pre-release version. To ensure that the kit performs optimally in this phase, we offer extensive support and ask pre-relase customers to share comments and raw data with us.
Both a Single-Lab (in house) and a Interlaboratory Validation have been performed, and show that the assay performs with an excellent sensitivity and precision:
-working range 0.1 - 25 ng Vtg/ml (250-fold)
- LOD= 0.02 ng/ml; LOQ= 0.09 ng/ml for plasma samples
- minimum dilution for plasma 1:50, whole body homogenate 1:100
- excellent correlation with and higher sensitivity than competitor fathead minnow Vtg kit and Biosense Carp Vtg kit
- In house: within-day precision (%CV): 4.5%, between-day precision (%CV): 9.9%
- Interlab (4 participant labs): within lab precision (%CV): 16.4%, between-lab precision (%CV): 18.6%

The validation reports are available to customers on request. 
The new Biosense fathead minnow Vtg ELISA kit comes with precoated plates, direct-labelled detection mAb, concentrated dilution buffer and a non-toxic developement solution. The total assay time is 2.5 hours.
Contact Biosense(biosense@biosense.com) for more information.

2004

23.11.04 New homologous fathead minnow VTG ELISA assay
A new homologous fathead minnow (FHM, Pimephales promelas) vitellogenin ELISA assay is now ready for interlaboratory validation. The assay, developed at Biosense, is built around FHM-VTG specific monoclonal antibodies developed by Professor Nancy Denslow at the University of Florida, Gainesville (USA). In-house testing has shown the assay to perform with an excellent sensitivity and working range (approx. 0.1 – 25 ng VTG/ml). The FHM VTG ELISA kit will come with precoated plates. In addition, the assay is simplified with a direct-labelled detection mAb, concentrated dilution buffer and a non-toxic development solution. The total assay time is 2,5 hours, reducing assay time with 1 hour compared with other Biosense Vtg ELISA kits. A commercial pre-release version of the kit will be ready for shipping in Q1 2005. Contact Biosense if you need more information.

22.11.04 ASP ELISA approved for further review
AOAC Presidential Task Force on Marine and Freshwater Toxins approved the Biosense ASP ELISA for further review. At the AOAC Annual Meeting held Sept. 19-23, 2004 in St Louis, USA, members of the recently established Task Force on Marine and Freshwater toxins met for the second time.  During an evening meeting for the 13 voting members, two completed interlaboratory studies, one proprietary kit for domoic acid by ELISA (Biosense Labs AS, Norway) and also a nonproprietary LC method for PSP toxins by precolumn oxidation (Lawrence et al, Health Canada) were discussed. Using the Methods Criteria, these two methods were voted on (all 13 voting members of the Task Force participated) and approved for review September 2004.
http://www.aoac.org/marine_toxins/task_force.htm
http://www.aoac.org/marine_toxins/update.htm
Contact person: Hans Kleivdal

26.05.04 New article about the ASP ELISA kit
An article ''ASP ELISA - A validated rapid assay for the determination of ASP levels in shellfish'' by Dr. Hans Kleivdal (download .pdf article) has just been published in the online journal Shellfish News. For further information about the ASP ELISA kit, please contact Dr. Hans Kleivdal.

26.05.04 Validation of the Atrazine ELISA kit
The Atrazine ELISA kit has been successfully validated by The Environmental Technology Verification Program (ETV). The results of the validation can be found at the US Environmental Protection Agency homepage.
Download the .pdf statement here.
Download the full .pdf report here.


10.05.04 Monoclonal bird- and alligator Vtg antibodies released for sale
Biosense introduces 3 new monoclonal antibodies against bird- and alligator Vitellogenin (Vtg).

Two of the antibodies ­ the ND-3C3 and the ND3G6 ­ are monoclonal mouse anti-bird vitellogenin. Both the antibodies binds with high affinity to vitellogenin from Japanese quail (Coturnix japonica), common tern (Sterna hirundo) and barn swallow (Hirundo rustica). The antibodies also cross-reacts with vitellogenin from other bird species.

The third new antibody is the ND-1E8, a monoclonal mouse anti-alligator vitellogenin. This antibody binds with high affinity to vitellogenin from American alligator (Alligator mississipiensis). Click here for more details

04.04.04 Biosense will attend the SETAC Europe meeting
Biosense Laboratories AS will attend the SETAC Europe meeting in Prague (18th to 22nd of April 2004) as exhibitor.
We welcome all new and existing customers to visit Biosense representatives as well as a representative from Japan EnviroChemicals, Ltd. (subsidiary of Takeda Chemical Industries, Ltd.) at booth number 5.
Among the news presented at the booth are our secound generation quantitative Vtg ELISA kits, new antibodies against bird and alligator Vtg, new antibodies against the androgen biomarker spiggin as well as the new, easy-to-use hormone and surfactant kits from Japan EnviroChemicals - distributed by Biosense in Europe.
See you in Prague!

25.02.04 New generation of vitellogenin ELISA kits
Biosense now launch our second generation of new and much improved quantitative Vitellogenin (Vtg) ELISA Kits, for quantification of the well established biomarker for oestrogen effects in fish. The kits feature pre-coated plates, new design and increased user-friendliness!

What is new?
The new kits are essentially the same assay and use the same components as the versions you may already be familiar with. They have simply been simplified!

New features are:

  • Pre-coated and blocked plates – we have already done the first 2 steps of the assay for you and reduced the assay time with 2 hours!
  • New design on kit box and protocol –developed in collaboration with Fuggibaggi Design, Bergen, Norway.
  • Convenient PBS-Tween tablets – makes preparation of the washing buffer easier.

    Want to know more about the quantitative vitellogenin ELISA kits? click here
    Please navigate through our Webshop to see all products available.

16.02.04 Training course in ELISA
In connection with the 6th International Conference on Cyanobacteria, Bergen, Norway, 21-27 June 2004, Biosense offers an intensive training course in the use of ELISA kits for the determination of microcystin in water samples, and for the determination of domoic acid in shellfish and water samples.
For further information and/or registration please download .pdf file

06.02.04 Biosense will attend the Rapid Methods Europe 2004
Biosense Laboratories AS will be represented at the Rapid Methods Europe 2004, (25-26th of March) conference by senior scientist Dr. Hans Kleivdal. At the conference, Dr. Kleivdal will present the case study ''ASP ELISA - The development and validation of a marine biotoxin ELISA for determination of domoic acid'' on Wednesday, March 26th, at 11.05.

To arrange a meeting with Dr. Hans Kleivdal at the conference, and/or to obtain further information on the ASP kit & our other products please contact us at biosense@biosense.com

29.01.04 Biosense now offers antibodies and Ab-based kit for detection of Cry proteins (GMO)
A microtiter based ELISA kit for detection and quantitation of Bt Cry1Ac and Cry1Ab (MON810, Bt11, Bt176)  endotoxin residues in corn tissues, cotton leaf tissues, and bulk corn  grain is now available. 
Antibody pairs and standards (Bt proteins) for  Cry1Ab, Cry1Ac, Cry1F, Cry2A, Cry3B, and Cry9C are available as well. Read more

29.01.04 Biosense now offers a range of new pesticide kits
As a part of an agreement with Abraxis LLC (USA), Biosense Laboratories now offers to the European market a series of new Ab based kits for measuring toxins, pesticides, and other unwanted chemical compounds in a broad range of sample matrices.  In addition to the Glyphosate ELISA kit and the Atrazine ELISA kit, Biosense now offers kits for Acetochlor, Cyclodienes, DDE/DDT, Diuron and Metolachlor. Read more 

2003

01.12.03 Biosense launches Webshop
Biosense is proud to present our new Webshop, where you can order and use credit card payment directly. As an introduction offer, we now give a 25% discount on all sales made through our Webshop throughout December 2003 (to the 30th of December) as long as the products are shipped within the 12th of January 2004.

To make use of this great offer just enter our Webshop and order. Please contact our web-master stale.wiborg@biosense.com if you have any questions.

After your first purchase, you will receive a login name and password, so that next time you purchase your details will automatically show. 

04.11.03 Biosense attends SETAC North America 24th Annual Meeting
Biosense attends as an exhibitor at the SETAC North America 24th Annual Meeting on the 9th-13th of November in Austin, Texas.

You can find our Marketing Director Frank F. Mikkelsen and our Scientist Janne K. Eidem at booth 33. Please visit our stand and learn more about our products.
Further information please contact us at biosense@biosense.com

02.10.03 New Vtg antibody released
Biosense introduces a new monoclonal antibody against medaka Vitellogenin (Vtg). The monoclonal antibody CK-1H11 binds with high affinity to vitellogenin and lipovitellin from Japanese medaka (Oryzias latipes). The antibody also cross-reacts with vitellogenin from a variety of different species including Atlantic cod (Gadus morhua), rainbow trout (Oncorhynchus mykiss), carp (Cyprinus carpio) and tilapia (Oreochromis niloticus). The antibody is well suited for use in ELISA and western blot. 

30.09.03 New assay for algal toxin detection to be presented at Aquaculture Canada 2003
Biosense Laboratory AS will be represented at the Aquaculture Canada 2003 conference by senior scientist Dr. Hans Kleivdal.
At the conference, Dr. Kleivdal will present the technology behind a new efficient assay for detection of Domoic acid, and data from an international collaborative validation study with method comparison with instrumental reference methods.

The title of the presentation, given on Wednesday, Oct. 30th 11.30, is: ASP Direct cELISA; a validated ASP rapid assay for the determination of Domoic acid in shellfish and seawater

To arrange a meeting with Dr. Hans Kleivdal at the conference, and/or to obtain further information on the ASP kit & our other products please contact us.

Read more about our ASP kit

13.08.03 Biosense supports VTG-ELISA QA in BEQUALM
The former EU-funded BEQUALM will be providing a non-profit, self-funded quality assurance scheme for biological effects measurements. Participation in the scheme will provide assistance with training, access to reference materials and ring testing of commonly used techniques. Biomarkers, including Vitellogenin (VTG) measurements, is one of the components of the new scheme. Biosense Laboratories AS will support program participants with free* ELISA kits for rainbow trout (Oncorhynchus mykiss) and Atlantic cod (Gadus morhua) VTG quantitation. Details of the program for 2003/2004 can be found on the BEQUALM website.

*availability limited on a first come-first served basis

01.08.03 Biosense attends Aqua Nor in Trondheim
Biosense attends as an exhibitor at the Aqua Nor 2003 (August 12-15) international exhibition to present our new ASP (amnesic shellfish poison) kit. Please visit our algal toxin expert Hans Kleivdal at our booth F529 to learn more about our ASP kit, and our other algal toxin kits in the pipeline.
Read more about our ASP kit

16.07.03 Biosense launches microcystin ELISA kit
As a part of an agreement with Abraxis LLC Biosense now launch an Ab-based microcystin ELISA kit to the European market. The kit is based on patented technology (WO 01/18059 A2) allowing congener independent determination of microcystin and nodulins.
Read more about the Microcystin Ab kit.

16.05.03 Biosense launches new ASP kit
After a successful validation study a pre-release version of the ASP (amnesic shellfish poison) direct cELISA kit is now available.
For further information about the kit, training courses etc. please contact us at biosense@biosense.com.

09.05.03 Biosense sponsor of 12th PRIMO symposium
The 12th bi-annual symposium Pollutant Responses in Marine Organisms PRIMO is this year hosted in Florida, USA May 9-13, 2003. The purpose of PRIMO 12 is to provide a forum for presentation and discussing of original research on toxicity, biomarkers, biotransformation, and biochemical, cellular, immunological and reproductive effects of chemical pollutants in aquatic organisms.
Biosense is delighted to support such an excellent forum for discussion about the environmental health, particularly in the marine context.

10.04.03 Visit Biosense at the SETAC-Europe meeting in Hamburg
Biosense Laboratories AS is attending the SETAC-Europe meeting in Hamburg (27th April- 1st May 2003) as exhibitor. You are welcome to visit Biosense representatives as well as a representative from Japan EnviroChemicals, Ltd. (Subsidiary of Takeda Chemical Industries, Ltd.) at booth number 20.
There will also be held a lecture on Development of ELISAs for Quantitative Analysis for Environmental Hormones and Surfactants by one of Takedas representatives on Monday, 28th April in Session 1A Environmental Analytical Methods.

02.04.03 Takeda launched new enterprise
As of April 1st, TAKEDAs Life-Environment Company were transferred to Japan EnviroChemicals, Ltd. (JEC), newly established as a 100% subsidiary of TAKEDA. TAKEDA has launched the new enterprise JEC to carry out research and development aimed at harmonic relationship with the environment around us.
Japan EnviroChemicals will move to a new office on April 14th, the address will be:

New Business Development Dept.
Japan EnviroChemicals, Ltd.
Seavans North 9F, 1-2-1 Minato-ku
Tokyo 105-0023
TEL: +81-3-5444-9891 FAX: +81-3-3278-9860

25.03.03 New vitellogenin standards now released
Biosense Laboratories now introduces 2 new vitellogenin (Vtg) standards for sale, the popular Zebrafish and Japanese Medaka. The lyophilized vitellogenin is well suited for use as positive control in western blot and ELISA, and freshly reconstituted Vtg may also be used as a standard in a quantitative ELISA.

21.03.03 Training courses at Biosense
Biosense is now offering short training courses in the use of the ELISA technology, sample preparation and the use of our Vtg EIA kits to test for endocrine disrupting effects in fish. If you are interested in a course or have any questions, please contact us at customerservice@biosense.com 

12.03.03 New review about vitellogenin
A review article about vitellogenin and zona radiata proteins and their use as biomarkers in endocrine disruptor screening by Dr. Augustine Arukwe and our CSO Anders Goksøyr has just been published in the online journal Comparative Hepatology (BioMed Central). It is freely available from: Comperative hepatology

10.03.03 New quantitative Medaka vitellogenin kit now released
Biosense is now proud to announce the release of our new quantitative medaka vitellogenin (Vtg) EIA kit, developed for reliable and sensitive detection of Vtg in samples from Japanese medaka (Oryzias latipes). As the first of the Biosense Vtg kits, the new Medaka Vtg EIA kit features pre-coated and pre-blocked microtiter plates, reducing assay time and increasing user-friendliness. For more information about the product please download the product description sheet in pdf. format or contact customer service at Biosense Laboratories (customerservice@biosense.com). 

25.02.03 New polyclonal Vtg antibody released for sale
Biosense is introducing a new Vtg (Vitellogenin) antibody. The product consists of rabbit polyclonal antibodies (affinity purifies IgG fraction) against vitellogenin from three-spined Stickleback (Gasterosteus aculeatus). The polyclonal antibody GA-306 binds with high affinity to vitellogenin in plasma samples from three-spined stickleback (Gasterosteus aculeatus). The antibody also cross-reacts with vitellogenin from rainbow trout (Oncorhynchus mykiss), tilapia (Oreochromis niloticus), sheepshead minnow (Cyprinodon variegatus), cod (Gadus morhua), turbot (Scophthalmus maximus) and ballan wrasse (Labrus bergylta). The degree of cross-reactivity differs between species and with the methods employed.
With this product expansion, it should be even easier to find a suitable product for your purpose in the Biosense product list.

10.02.03 Vacancy at Biosense
Biosense Laboratories AS has a 15 month vacancy for a laboratory technician starting 01.04.2003. Work tasks involve immunological techniques, protein purification and tissue culture in connection with production and quality control of our products for sale. Applicants should have relevant education and some work experience. English oral and written skills required.
For contact information check our vacancy page

04.02.03 Reference list published on Biosense web
Biosense have now published our reference list on our web-page and will regulary update this page. We have listed some of the litterature, relevant for research on biomarkers, pollutants, EDC's and environmental diagnostics. we will also publish our posters on our web in the near future.
If you have any suggestions to references that should be on the list please let us know (customerservice@biosense.com)

22.01.03 New monoclonal Zrp antibodies released for sale
Biosense is introducing three new Zrp (Zona radiata proteins) antibodies prepared against Atlantic salmon (Salmo salar) Zrp, (prod. No. Z03402101, Z03402102 and Z03402103). The antibodies have different affinities for the three Zrp monomers. They also cross-react with other fish species such as rainbow trout (Oncorhynchus mykiss), Artic charr (Salvelinus alpinus), turbot (Scophthalmus maximus) and cod (Gadus morhua). Click on the links for more information.
With this product expansion, it should be even easier to find a suitable product for your purpose in the Biosense product list.

13.01.03 Biosense launches new web-page
Biosense has released several new products over the last few months. To present the new product information together with the increasing amount of news and general information in the field of environmental diagnostic, Biosense has launched a new version of our web-site. We hope you find the information on the web-site is relevant and easy to access. If you have comments, questions or suggestions to fhurther improvement of the web-site please let us know.

10.01.03 Biosense attends SOT in Salt Lake City
Biosense attends as an exhibitor at the ToxExpo at the 2003 Society of Toxicology (SOT) Annual Meeting on the 9th-13th of March. You can find our Marketing Director Frank F. Mikkelsen at booth 1416. Please visit our stand and learn more about our products.
Other meetings Biosense is attending as an exhibitor this year is;
SETAC Europe, Hamburg
AquaNor, Trondheim
SETAC USA, austin, Texas
Further information about these meetings will be published at a later stage

2002

25.11.02 New quantitative Medaka vitellogenin kit
Biosense is proud to announce the pre-release of our new quantitative medaka vitellogenin (Vtg) EIA kit, developed for reliable and sensitive detection of Vtg in whole body homogenates of the Japanese medaka (Oryzias latipes). For more information about the product please download the product description sheet in pdf. format or contact customer service at Biosense Laboratories (customerservice@biosense.com).

03.09.02 Takeda and Biosense agree on collaboration
Bergen, Norway, September 3rd, 2002
Biosense Laboratories AS, Bergen, Norway, and Takeda Chemical Industries Ltd., Tokyo, Japan, announced today the signing of a marketing agreement. The purpose of the agreement is for Takeda to distribute and sell Biosense's Family of Biomarker ELISA kits in Japan and for Biosense to distribute and sell Takeda's ELISA kits for Environmental Pollutants in Europe.

Takeda’s Life-Environmental Company has utilized the very sensitive ELISA technology to develop kits to detect harmful compounds in the environment and Biosense has used the same technology platform to develop a family of assay to test for biomarkers, the biological response to pollutants.

The two companies’ biotechnology-based products offer cost-effective, rapid and easy-to-use solutions for monitoring of environmental pollution. The Biosense Biomarker Assay can detect the biological effect of pollution at an early stage -in compliance with the precautionary principle, and the Takeda ELISA Kits for Environmental Pollutants can detect and quantify the concentration of the chemicals causing the harmful effects.

“The two product ranges supplement each other perfectly, and the agreement will strengthen the two companies’ position as world leaders in the fields of environmental diagnostics.” agree Mr.Wiborg, CEO at Biosense and Dr. Kobayashi, President of Life-Environment Company at Takeda.

“This agreement gives us the opportunity to offer a more complete solution to our customers and accelerate the growth of our business. The co-operation may also strengthen our ability to further develop our range of products in this field,” continues Mr. Wiborg and Dr. Kobayashi.

Biosense Laboratories AS is a leading supplier of products and test systems for detecting and analysing xenobiotics and toxins in food, chemical products and in the environment. Biosense products provide important knowledge about properties and quality of processes, consumer goods and the environment. The use of Biosense tests gives increased safety for the supplier, the user/consumer, and the environment, as well as added product value and competitive advantage for the industry itself.

Takeda’s Life-Environmental Company, a division of Takeda Chemical Industries, Ltd., is a pioneering supplier of ELISA test kits to detect surfactants, endocrine disrupting chemicals, and natural hormones. Takeda ELISA systems, in tandem with simplified sample pre-treatment optimally developed for each ELISA, provide a high correlation with conventional instrument analysis. The adoption of Takeda ELISA and recommended preparation protocol is a simple, cost-effective solution to evaluate the degree of contamination in environment.

12.08.02 Further research needed on endocrine disrupting chemicals
WHO released new publication, that concludes that further research is needed to determine whether human health has been adversely affected by exposure to EDCs. Studies on the effects of EDCs on infants and children are especially critical, since exposure during early childhood development may have irreversible effects.

16.07.02 Paracelsian Announces License Agreement for Europe and Letter of Intent
ITHACA, NY, June 26, 2002 — Paracelsian, Inc. (PRLN:OTCBB) announced today the signing of a License Agreement with Biosense Laboratories AS, a Norwegian corporation, for the exclusive license to distribute and sell Paracelsian’s Ah-IMMUNOASSAY® Kits in Europe.

Paracelsian’s Ah-IMMUNOASSAY® Kit is a highly sensitive, convenient and cost effective testing system for the detection and quantification of highly toxic environmental chemicals generally known as dioxin and dioxin-like compounds.

There is a real need in Europe for our Ah-IMMUNOASSAY® Kit and this agreement establishes Paracelsian’s technology within this diverse and expanding market said NoriYoshi Inoue, President and CEO.

Biosense is pleased to be bringing the Ah-IMMUNOASSAY® Kits and/or analytical services to the European market, stated Audun Wiborg, CEO. We will begin immediate entry into the marketplace and we are optimistic about creating and maintaining a solid customer base, continued Mr. Wiborg.

Paracelsian and Biosense also announce today the singing of a Letter Of Intent to:

1. Develop joint Ah-IMMUNOASSAY® Kit marketing activities, including participation at the Dioxin 2002 Conference in Barcelona, Spain to be held in August 2002.
2. Develop a joint marketing and sales agreement for the distribution and sale of Biosense products in the United States.

Since our companies have similar goals, this Letter Of Intent strengthens our developing relationship and will allow us to accelerate the growth of both businesses, agreed Mr. Inoue and Mr. Wiborg.

Biosense is a biotech company focusing on the development and production of immunoassays and bioassays for environmental monitoring, chemical product testing and consumer safety industries.

Paracelsian is a unique biotechnology company with three primary areas of focus. Paracelsian develops technologies useful in the detection and monitoring of environmental contaminants such as dioxin. Second, Paracelsian develops functional bioassays, which are the basis of its BioFIT™ Quality Assurance program for herbs, botanicals and other dietary supplements. And finally, Paracelsian's Internet business leverages extensive relationships in China, along with expertise in nutritional science, to provide an exchange of unique health products and research services.

Notice: This news release may contain forward-looking statements. Investors are cautioned that such forward-looking statements involve risks and uncertainties, including but not limited to, the results of research and development efforts, the effect of regulation by the United States Food and Drug Administration and other agencies, the impact of competitive products, product development, commercialization and technological difficulties, and other risks detailed in the Company’s periodic reports filed with the Securities and Exchange Commission.

No forward-looking statement is a guarantee of future results or events, and one should avoid placing undue reliance on such statements.

CONTACT:
Audun Wiborg, CEO of Biosense Laboratories AS, HIB-Thormøhlensgt. 55, 5008 Bergen, 0047-55 54 39 92

14.05.02 New quantitative zebrafish vitellogenin kit
Biosense are now proud to announce the release of our brand new quantitative zebrafish vitellogenin (Vtg) EIA kit, developed for reliable and sensitive detection of Vtg in whole body homogenates of zebrafish (Danio rerio). At the Society of Environmental Toxicology and Chemistry (SETAC) annual meeting in Vienna (12-16th of May), a raffle of the new kit will be performed to mark this special occasion. For more information about the product please visit our exhibition at the SETAC meeting, download the product description sheet in pdf. format or contact customer service at Biosense Laboratories (customerservice@biosense.com).

24.04.02 Biosense and Paracelsian announce Letter of Intent
ITHACA, NY, April 24, 2002 –Paracelsian, Inc. (PRLN: OTCBB) announced that it has signed a Letter of Intent with a company in Norway to cooperate in the continued improvement of Paracelsian’s cost-effective and user-friendly technology for the screening of environmental samples for dioxin and dioxin-like chemicals called the Ah-IMMUNOASSAY®.

The Letter of Intent is between Paracelsian, Inc. and Biosense Laboratories AS, a company located in Bergen, Norway. Both companies have mutual goals of introducing new technologies for high quality, user friendly and rapid representation in the environmental and consumer safety industries.

Paracelsian and Biosense agreed to jointly market and sell Paracelsian’s Ah-IMMUNOASSAY® Kits and/or analytical services. By May 22, 2002 the parties will develop a one year trial period sales agreement that will include milestones. Additionally, the parties agreed to participate together on research and improvement of current methodologies for sample preparation and analysis, as well as improvement of kit components and packaging.

“By operating in the environmental industry Biosense has nurtured contacts with key players in this field within thirty countries,” said NoriYoshi Inoue, President and CEO of Paracelsian. “They have all the necessary skills and understanding to help us ensure that our Ah-IMMUNOASSAY® technology generates the utmost attention-getting appeal to the widest range of customers in Europe,” continued Inoue.

“Entering into a co-operation with Paracelsian will rapidly expand our product range with an assay with a great market potential. Paracelsian’s Ah-IMMUNOASSAY® Kit fits very well in with our own product range,” said Audun Wiborg, CEO of Biosense. “Together with our own technology we see a potential for further simplifications as well as new applications,” concluded Mr. Wiborg.

Biosense is a biotech company focusing on the development and production of immunoassays, and bioassays for environmental monitoring, chemical product testing and food safety studies.

Paracelsian is a unique biotechnology company with three primary areas of focus. Foremost, Paracelsian develops technologies useful in the detection and monitoring of environmental contaminants such as dioxin. Second, Paracelsian develops functional bioassays, which are the basis of its BioFIT™ Quality Assurance program for herbs, botanicals and other dietary supplements. And finally, Paracelsian's Internet business leverages extensive relationships in China, along with expertise in nutritional science, to provide an exchange of unique health products and research services.

Notice: This news release may contain forward-looking statements. Investors are cautioned that such forward-looking statements involve risks and uncertainties, including but not limited to, the results of research and development efforts, the effect of regulation by the United States Food and Drug Administration and other agencies, the impact of competitive products, product development, commercialization and technological difficulties, and other risks detailed in the Company’s periodic reports filed with the Securities and Exchange Commission.

No forward-looking statement is a guarantee of future results or events, and one should avoid placing undue reliance on such statements.

CONTACT:
Audun Wiborg, CEO of Biosense Laboratories AS, HIB-Thormøhlensgt. 55, 5008 Bergen, 0047-55 54 39 92

14.02.02 New product numbers at Biosense introduced
Due to the implementing of a new electronic product navigating system at Biosense new product numbers have been introduced. If you have problems finding the right product do not hesitate to contact us: customerservice@biosense.com 

07.01.02 US consorted action on Endocrine disrupter test development and validation
The US Congress has funded a five year, multi-million dollar consorted action on Endocrine disrupters (EDs) test guideline development and validation. The ED validation programme is run as a joint action betwen US EPA, Battelle and various sub-contractors with the aim to advance the knowledge on testing methodologies in major sectors like mammalian, avian, amphibian and fish toxicology. The project will include a review of the available literature on chemical and ED-related research, prioritising of suspect chemicals, development and validation of testing methodologies and procedures for future implementation in regulatory testing of these chemicals. 

2001

03.12.01 Biosense promotes new products at SETAC-USA
Biosense Laboratories attended the 22nd annual North America meeting in the Society of Environmental Toxicology and Chemistry in Baltimore (November 11-15th) with a small exhibition. Although the attendance to the meeting was low due to the last months international terror events, this years meeting proved to be one of the better ones ever. Part of this success is caused by the customer interest in the newly developed quantitative kits for vitellogenin from carp/fathead minnow (Prod. No. V5003), rainbow trout (Product no. V5004) and the quantitative 11-ketotestosterone EIA kit (Prod. no. K5001). Furthermore, research on Endocrine disrupters was this year given considerable attention with a full day platform session as well as 3 days of poster sessions. Biosense would like to congratulate the organisation committee for a well-executed meeting which make us want to come back for next years SETAC conference in Salt Lake City.

21.02.01 Norwegian Ministry of Environment bans endocrine disrupters
The Norwegian Ministry of Environment is among the first international governmental organs to ban industrial use of endocrine disrupters, either as pure compounds or as formulations. The ban, which takes effect in January 2002, aims to prevent the production, import, and use of the alkylphenols octylphenol and nonylphenol, and their ethoxylate derivatives. These chemicals are known to act as estrogen mimics and have been identified as the most common industrial agents with endocrine modulating effects. It is acknowledged that the Norwegian Ministry of Environment is applying the precautionary principle into practice by issuing regulations on endocrine disrupters. Contact the Norwegian Ministry of Environment or Norwegian Pollution Control Authority for more information.

15.10.01 New Endocrine disrupter products released for sale
Biosense is proud to present the new quantitative EIA kit for rainbow trout (Oncorhynchus mykiss) vitellogenin (V01004401) and 11-ketotestosterone (K20000401). The new kits, which have been under development the last year, have passed rigorious testing in our customer based validation programme and is now ready for sale. We have, on basis of feedback from our many pre-release customers, made some improvements to increase the sample assay capacity as well as issue the new vitellogenin kits in a 96 wells (1-plate) version. The two kits will be offered customers at a introductory discount that will last throughout this year. For more information, please refer to the complete product description (V01004401 and K20000401) or contact customer service at Biosense Laboratories AS. 

10.10.01 Biosense sponsor of the Biomarkers´2001 conference
The first international Biomarker conference (Biomarkers´2001) was held in Porto (Portugal) on September 24-26. The meeting, which gathered over 150 scientists from around the world, focused on the use of biological markers in detection of pollutants and pollutant effects in wildlife, farm species and humans. Special emphasis was given to biomarkers of exposure and/or effect as well as biomarkers of endocrine disruption. Biosense presented several new products, in particular the quantitative rainbow trout vitellogenin EIA kit (Product no. V5004) and the quantitative 11-ketotestosterone EIA kit (Prod. no. K5001), which both will be released October 15th. The new kits received considerable attention, illustrating that biomarkers of endocrine disruption is an evolving issue within ecotoxicology. Biosense found the conference to be rewarding both with regard to customer relations and the high quality discussions of the scientific sessions, and will consequently give high priority to sponsor the next bi-annual Biomarker meeting in Berlin.

03.09.01 Biosense foster new biotech start-up
A new biotech-company called Uni-Targeting Research AS has been established in Bergen, based on research at the Department of Biochemistry and Molecular Biology, University of Bergen, in collaboration with the University of Newcastle (UK) and University of Barcelona (Spain). The company will devote its time to developing a patented technology for producing important biomedical proteins from mammalian cell factories by introducing appropriate 5’ and 3’ mRNA targeting (UTR) signals. Professor Ian F. Pryme will work as R&D Director for the company at 20% of his time, with dr. scient. Beate Stern as Senior Scientist. Biosense Laboratories AS is hosting the administration and business development of the company in addition to being one of the founders.

15.08.01 New staff wanted to expand the Biosense organisation
Biosense is, as a consequence of expansion of our activities and commercialisation of new products, seeking new employees. The company, which now employ 12 people, are looking for 5 new candidates for R&D, production, marketing and sales. We offer competitive packages in a well functioning and positive working environment that focus on market leading technology. The company is highly dynamic, and may introduce interesting career opportunities. See the complete job descriptions for details. Application deadline is the 31th of August


15.07.01 Biosense sponsor of 11th PRIMO symposium
The bi-annual event of the International Symposium on Pollutant responses in Marine Organisms (PRIMO) was this year hosted by the University of Plymouth (UK) from the 10-13th of July. The meeting, which gathered over 200 scientists from around the world, focused on mechanisms of toxicity, biotransformation, and assessment of biochemical, cellular, physiological, genetic, histopathological, immunological and reproductive effects of chemical pollutants in aquatic organisms. Biosense is delighted to support such an excellent forum for discussions about the environmental health, particularly in the marine context.

18.06.01 Successful launch of first EIA short course
Biosense arranged the first 2-day EIA course for a major industrial laboratory last week. The short course, which included both theoretical presentations and practical exercises in the use of the new quantitative rainbow trout vitellogenin EIA kit, went according to schedule. After introduction to the field of endocrine disruption, fish test design and EIA assays, the participants were guided through the assay by the help of Biosense representatives. By the end of the course, it is believed that all participants received the necessary theoretical as well as technical skills to perform the assay on their own, only guided by the assay protocol. Biosense will in the future arrange similar short courses either on-site or at the Biosense (or distributor) facility. For further information, please contact customer service at Biosense Laboratories AS (customerService@biosense.com).

07.05.01 New Biosense products presented at SETAC-Europe
During the SETAC-Europe meeting in Madrid (6-10th of May), Biosense Laboratories presented several products developed since the SETAC-meeting in Brighton (UK) last year. Of these products, the newly developed quantitative rainbow trout vitellogenin EIA kit (product no. Pre-V5004) received considerable attention, illustrating that endocrine disrupters is still a very important topic within ecotoxicology. Among the other products being presented, the new assay for 11-ketotestosterone (product no. Pre-K5001) was well received among fish endocrinologists as well as ecotoxicologists. Biosense would like to congratulate the organisation committee of SETAC with a well-executed conference in regard to the scientific, commercial and social programme.

01.05.01 Audun Wiborg apppointed as new Managing Director
Biosense is proud to present the new Managing Director (CEO), Audun Wiborg. Audun has more than 30 years of experience in management and business development within aquaculture, banking, process instrumentation, telecommunication and information technology. He has been working closely with Biosense Laboratories AS through the position as chairman of the Board of Directors from May 1998 until April 2001. Biosense is confident that his broad business experience and enthusiasm may prove invaluable for the company development in years to come. Audun can be reached by e-mail (audun@biosense.com), and by phone (+47 55 54 39 92).

02.04.01 Biosense on State visit to Japan
In connection with the visit of Their Majesties King Harald V and Queen Sonja of Norway to Japan in March, Biosense Laboratories AS was invited to give a presentation at the Japan-Norway Science and Technology Seminar in Tokyo on March 27, 2001. Professor, CEO and founder of Biosense, Dr. Anders Goksøyr, gave a presentation entitled Biotechnology in monitoring the marine environment to an audience of around 100 invited guests at Hotel New Otani in Tokyo. The seminar’s plenary session was opened by Ms. Grete Knudsen, the Norwegian Minister of Trade and Industry, and Mr. Yoshinuro Ono, Senior Vice-Minister of Education. Culture, Science and Technology of Japan. Mr. Otto Gregussen, the Norwegian Minister of Fisheries, gave an openeing statement at the Marine Biotechnology Session. Other speakers at this session were Dr. Jan Raa, Science Director and founder of Biotec ASA, Dr. Øystein Lie, CEO and founder of GenoMar ASA, Dr. Fumio Takashima, professor and President of Tokyo University of Fisheries, Dr. Takashi Aoki, professor of Tokyo University of Fisheries, and Dr. Shigeaki Harayama, director of Kamaishi Laboratories, Marine Biotechnology Institute Co. At the luncheon, King Harald V was present as the Guest of Honour and gave a speech to the seminar delegates.

19.03.01 New quantitative carp Vtg kit to be released at SOT
Biosense will release the newly developed quantitative carp vitellogenin (Vtg) EIA kit at the Society of Toxicology (SOT) annual meeting in San Francisco (25-29th of March). The new kit, which has been developed for reliable and sensitive detection of Vtg in plasma and whole body homogenates of fish, is intended used for basic fish endocrinology as well as investigations of endocrine disruption in fish. Although developed for carp (Cyprinus carpio), it may also be used for quantification of Vtg from fathead minnow (Pimephales promelas), another cyprinid test species. A daily raffle of the new kit will be performed throughout the conference to mark this special occasion. For more information about the product (prod. no. vtg-103), please visit our exhibition at the SOT-meeting, download the product data sheet in pdf. format or contact customer service at Biosense Laboratories (customerService@biosense.com).

21.02.01 Biosense celebrates 5 year anniversary
Biosense celebrates 5 years in business for the environment. The company was founded by Professor Anders Goksøyr at the High Technology Centre in Bergen, Norway, on February 21, 1996, based on research and competence in biotechnology and ecotoxicology at the University of Bergen. After 5 years, the biomarker concept for pollutant effects is still one of the primary focal points of the company, thanks to the many good customers of the products. The aim for the future is to widen the product line into other aspects of environmental diagnostics and food safety, thus setting the course for new research challenges and search for innovative technology in the years to come.

04.01.01 New polyclonal anti-zebrafish Vitellogenin Antibody
A new polyclonal antibody (PAb) against vitellogenin (Vtg) from zebrafish (Danio rerio) is ready for sale (Prod. no. Vtg-18). The PAb is produced in collaboration with Francois Brion and Dr. Jean-Marc Porcher at the Institut National de l´Environnement Indistriel et Des Risques, Ineris (France). The antibody shows good crossreactivity towards Vtg from common carp (Cyprinus carpio) and fathead minnow (Pimephales promelas). Check our product list or contact customer service for further information on specificity and price.

03.01.01 New polyclonal anti-fish CYP1A Antibody
A new polyclonal antibody (PAb) against the peptides 190-204 and 282-296 of rainbow trout (Oncorhynchus mykiss) cytochrome P450 (CYP1A) is ready for sale (prod. no. Cyp-11). The antibody shows good crossreactivity towards CYP1A in liver samples from a wide variety of species, including rainbow trout (Oncorhynchus mykiss), Atlantic salmon (Salmo salar), Atlantic cod (Gadus morhua), carp (Cyprinus carpio), flounder (Platichthys flesus), sheepshead minnow (Cyprinodon variegatus) and gilthead seabream (Sparus aurata). Check our product list or contact customer service for further information on specificity and price.

2000

01.12.00 Biosense introduces new website with added features
Biosense Laboratories is proud to introduce our new website at the end of this year. The homepage have been improved in comparison to the old version by including updated product descriptions (web site documents and downloadable pdf-files), frequently asked questions (FAQs), links, updated news and a website search engine. Our aim with introducing the new website is to make information more accessible, enhance the customer support and stimulate the use of the web site for information exchange. Comments and advice on website contents may be communicated to the Biosense marketing department.


20.11.00 Successful exhibition at the Annual SETAC-USA Meeting
Biosense Laboratories participated at the 21st annual meeting in the Society of Environmental Toxicology and Chemistry (Nashville, 12-16. November 2000) with a small exhibition for the third time in a row. During the exhibition, considerable attention was given the future release of the 11-ketotestosterone, rainbow trout and cyprinid (carp and fathead minnow) vitellogenin ELISA kits early next year. Considerable interest was also identified for the detection of Vtg in non-OECD species like sea bass, killifish and bluegill sunfish. The scientific meeting, which was attended by over 3000 people, was to a great extent focused on the use of biomarkers in the fields of endocrine disruption, metal and dioxin/PCB toxicity. Although covering several aspects, considerable emphasis was given the evaluation of different test methods, chemical screening and environmental monitoring. Biosense found the conference to be rewarding both with regard to customer relations and the scientific discussions of the sessions, and will be present at the next year SETAC-meeting in Baltimore.

03.11.00 Development of Quantitative Vitellogenin ELISA kits
New quantitative ELISAs for analysis of vitellogenin (Vtg) in standard OECD species like rainbow trout (Oncorhynchus mykiss), carp (Cyprinus carpio), fathead minnow (Pimephales promelas), zebrafish (Danio rerio) and Japanese medaka (Oryzias latipes) are currently being developed and validated by Biosense Laboratories AS. The new kits are based on a sandwich format (capture ELISA) with superior performance in regard to sensitivity and reproducibility. The new products will cover the need for analysis of Vtg in basic fish endocrinology as well as in chemical screening and environmental monitoring of endocrine disrupting chemicals according to recommendations given by the OECD (See news of 01.10.00). Biosense anticipate to release the new rainbow trout and cyprinid kit (carp and fathead minnow) early next year (2001), whereas kits for zebrafish and Japanese medaka will be released later the same year.

01.10.00 OECD recommends fish vitellogenin in fish endocrine disrupter tests
The 4.th meeting of the OECD Task Force of Endocrine Disrupter Testing and Assessment, EDTA in Paris May 12.th endorsed previous recommendations to include vitellogenin (Vtg) as an endpoint in a short term screening assay for endocrine disrupting chemicals with estrogenic effects in fish.

In the recommendations from EDTA, Vtg is acknowledged as a good biomarker for estrogenic and anti-estrogenic effects in fish. It was generally agreed that Vtg should be implemented in combination with gross morphology and gonadal histology as core endpoints in short term endocrine disrupter screening of chemicals. The EDTA also proposed that future testing methods for EDCs in fish should be designed to be applicable to different species, in particular zebrafish (Danio rerio), fathead minnow (Pimephales promelas), carp (Cyprinus carpio), medaka (Oryzias latipes) and rainbow trout (Oncorhynchus mykiss).

26.09.00 New Vtg MAbs ready for sale
Several new monoclonal antibodies (MAbs) against Vtg in different fish species are ready for sale. The MAbs are licensed from the University of Florida, and show cross-reactivity to carp, fathead minnow, zebrafish, goldfish, mullet, striped bass, rainbow trout, killifish, tilapia, etc. Check our product list or contact biosense@biosense.com for further information on specificity and price. 

11.07.00 11-ketotestosterone antibody licensed from University of Sheffield (UK)
In a License Agreement with the University of Sheffield (UK), Biosense has aquired a set of polyclonal antibodies to 11-ketotestosterone, a male-specific steroid and potent androgen found in fish (Cuisset et al., 1994). Biosense is currently working on developing a sensitive ELISA-based kit for this steroid, which may be useful in studying reproductive development and endocrine disrupting effects in fish and other vertebrates.

08.06.00 Several new vitellogenin antibodies licensed
In a License Agreement between Biosense Laboratories AS and University of Florida (UF), Gainesville (FL, USA) signed June 8, 2000, Biosense has licensed a series of hybridoma cells producing monoclonal antibodies towards various fish vitellogenins (Vtg) developed by Dr. Nancy Denslow at UF’s Protein Chemistry and Molecular Biomarkers Laboratory. The antibodies have specificities towards Vtg from carp, fathead minnow, medaka, killifish, sheepshead minnow, largemouth bass, sturgeon, brown bullhead, and a number of other species.

The antibodies should prove invaluable to researchers in endocrinology and toxicology studying endocrine disruptors and reproductive disturbances in fish. The antibodies will be available as products around October 2000, and some of the antibodies will be further developed into ELISA kits.

08.05.00 Biosense to develop new in vitro test for diarrhetic shellfish poison (DSP)
Biosense has aquired the material rights for developing an in vitro test for phosphatase targeting toxins in shellfish and drinking water (patent pending). A collaborative R&D project with the University of Bergen, the Norwegian Veterinary College in Oslo, and shellfish growers in Norway, has received approx. 100,000 Euro from the Norwegian Research Council (NFR) for developing this test, and for validating it towards the mouse in vivo test as an alternative method for screening diarrhetic shellfish poison (DSP) in mussel. The test will also be developed into a test for cyanobacterial toxins in drinking water. Biosense is currently discussing collaborative projects with companies in the USA and Canada in this development. 

01.05.00 Biosense appoints Knut-Erik Tollefsen as Director for Market Development
Biosense is pleased to introduce our new associate, Knut-Erik Tollefsen, who will work as Director for Market Development from our Bergen headquarter. Knut-Erik has a background in toxicology, and has just finished his PhD programme working on endocrine disruptor effects in fish at the University of Oslo. He has been an enthusiastic customer of Biosense antibodies during his laboratory work, bringing all the necessary experience for working with developing customer relationships and marketing plans.

28.04.00 Biosense signs distribution agreement with Cayman Chemical Co.
At a meeting in Bergen, Norway, on April 28, 2000, Dr. Kirk Maxey, President of Cayman Chemical Co., and Dr. Anders Goksøyr, CEO of Biosense Laboratories AS, signed a two-year exclusive distribution agreement for Biosense products in the Western Hemisphere. Cayman will from now on represent Biosense, distribute and market our products in USA, Canada, Mexico, Latin America and South America. Customers in these countries should address Cayman for country specific information about pricing and shipping details, but are welcome to contact the Biosense main office for any other questions regarding our products. 

06.03.00 First Quantitative Rainbow Trout Vitellogenin ELISA Kits shipped
After a series of technical hurdles, the first boxes of our Quantitative Rainbow Trout (Oncorhynchus mykiss) VTG ELISA Kit (prod. no. Vtg-102) were shipped to customers in Canada, United Kingdom, and Belgium this week. Using lyophilized rainbow trout Vtg as a standard, these kits can be shipped everywhere without the need for expensive and troublesome dry ice shipments.

Vtg-102 comes in two sizes, with 192 and 480 wells (2 and 5 plates, respectively), with all necessary reagents for running the ELISA, and an instructive protocol. The competitive ELISA employed in the kit has a wide working range (150-6,000 ng Vtg/ml). The kit is recommended for industrial safety laboratories, ecotoxicological testing laboratories, and academic research laboratories involved in chemical product testing, envionmental monitoring, and ecotoxicological research using the rainbow trout as test species. The kit will be available at an introductory 40% discount through June 2000.

22.02.00 Biosense signs co-operation agreement with Novartis Crop Protection
Biosense has signed a one-year cooperation agreement on testing and optimization of an ELISA kit for vitellogenin detection in cyprinid test species with Novartis Crop Protection. The kit will be based on the polyclonal carp Vtg antibodies (prod. no. Vtg 14) developed by Dr. Charles R. Tyler at Brunel University (UK), shown to give reliable results also with other cyprinids, e.g. the fathead minnow, zebrafish, goldfish, roach etc. (Tyler et al., 1996; 1999). 

12.02.00 Biosense appoints distributor for Japan
Biosense Laboratories AS has signed an exclusive two-year agreement with Immuno-Biological Laboratories Co., Ltd. (IBL), Japan, to serve as distributor for Biosense products in Japan, starting from January 1, 2000. IBL is specializing in immunochemical reagents and tests, and has its own production plant in Fujioka-city, Gunma Prefecture outside Tokyo. IBL has been serving the Japanese market since 1982.

Japanese customers should contact IBL directly for information on Biosense products and prices at tel. 0274-22-2888, or fax: 0274-23-5746

03.01.00 Four new Biosense vitellogenin antibodies introduced!
Biosense opens the new Millennium by introducing four new polyclonal antibodies to fish vitellogenins (Vtgs), making the range of Biosense Vtg antibodies even broader. The new antibodies have been developed and made available by scientists in England and Sweden, and are prepared against carp, Cyprinus carpio (Prod. no. Vtg-14), cod, Gadus morhua (Prod. no. Vtg-15), turbot, Scophthalmus maximus (Prod. no. Vtg-16), and wolffish, Anarhichas lupus (Prod. no. Vtg-17), but all with a broad cross-reactivity towards other species. E.g., the carp Vtg antibody has been shown to work well with both fathead minnow (Pimephales promelas), and zebrafish (Danio rerio), popular small test species for toxicity studies. With this product expansion, almost any resesarcher working with fish Vtg should be able to find a suitable antibody for his or her purpose in the Biosense product list. Biosense is in the process of developing Vtg-ELISA kits for some of these antibodies.

1999

02.12.99 Norwegian Design Award 1999 to Biosense
The new ELISA kit box from Biosense has attracted interest from customers and distributors worldwide, not only for its contents. On December 2, 1999, the Biosense ELISA kit box was awarded the Norwegian Design Award 1999 for its esthetic, innovative and practical design. The kit box is made of recyclable materials, and was designed by Johnny Snapa and Christian Rugaard at Odin Industridesign, Oslo, Norway. If you want to have a closer look, order one of our ELISA kits! 

01.12.99 Biosense Laboratories AS has developed a quantitative Vtg ELISA kit
Biosense -Vtg 102 - The system is a competitive enzyme-linked immunosorbent assay (ELISA) based on monoclonal vitellogenin antibodies developed to quantify Vtg in the rainbow trout (Oncorhynchus mykiss), a standard OECD test specie used in many testing laboratories. The ELISA kit works very well also with other salmonids such as Atlantic salmon (Salmo salar) and Brown trout (Salmo trutta). The system was developed in collaboration with Dr. Charles Tyler, Dept. of Biological Sciences, Brunel University (UK) as part of a EUREKA project.

15.11.99 Development of a quantitative ELISA-assay
EUREKA: Project nr.: E! 2240ACRONYM: BIOSENSEUMBRELLA: EUROENVIRON
SUMMARY:
Biosense Laboratories AS aim was to develop a quantitative ELISA system for fish vitellogenin (VTG) testing that would meet the criteria for an OECD test. The company has developed monoclonal antibodies against fish vitellogenin and a semi-quantitative ELISA-kit is now in the pipeline. Within OECD and US EPA the need for a standardized vitellogenin test has been expressed by the OECD and US EPA. A standardized test that could be implemented in OECD guidelines for testing of chemicals, would need to be quantitative.

The challenges in developing a quantitative ELISA assay lies in:


  • developing monoclonal antibodies that target the fish species relevant for OECD guidelines and US EPA testing,
  • developing a protocol for simple, rapid, and reproducible scoring of sample values in a quantitative way, and
  • producing the necessary standard reagents for internal calibration of the signal, with a sufficient stability for transport and storage with the customer.

Biosense Laboratories AS is collaborating with AstraZeneca and Brunel University. AstraZeneca, division Brixham Environmental Laboratory has expertise in toxicity testing and development of new testing protocols based on ecotoxicological reasearch. Brunel University has strong experience in developing similar protocols from previous research on vitellogenin in fish. In the Eureka-project Biosense will collaborate with AstraZeneca and Brunel University to develop the vitellogenin ELISA test into a new commercial product that could form the «Gold Standard» for this type of testing.